Genetic toxicology
Study design, assay selection, unexpected result evaluation, and integrated interpretation of in vitro and in vivo data.
Independent scientific consulting
Clarity for complex toxicology decisions.
Genetic and investigative toxicology expertise for study strategy, regulatory interpretation, and human-relevant testing approaches.
Discuss a project35+ yearsInvestigative toxicology research
PhD · DABT · ATSScientific and professional credentials
OECD working groupGenetic Toxicology Expert Working Group member since 2014
What we do
Scientific depth where it matters.
Recio LLC supports pharmaceutical, biotechnology, chemical, and related research teams from test strategy through interpretation.
Assessment & submissions
Scientific review of genotoxicity packages, testing strategies, protocols, and data prepared for regulatory decisions.
New approach methodologies
Human-relevant liver and lung models, 3D respiratory systems, and method development to answer specific safety questions.
Toxicogenomics
Transcriptomic evidence, mode-of-action analysis, and biomarker approaches integrated with conventional toxicology endpoints.
Assays & validation
Experience with bacterial mutation, micronucleus, comet, and emerging mutation assays, including troubleshooting and method transfer.
Independent scientific review
Focused review of study plans, data interpretation, risk questions, and emerging technologies for research programs.
Development support
From preclinical evidence to clinical progress.
We help clients investigate safety findings, address evidence gaps, and develop a clear scientific path toward clinical development. Whether preparing to move from preclinical to clinical studies or responding to a clinical hold, we bring genetic toxicology, regulatory insight, and informatics together to support defensible decisions.
How we work
From a difficult finding to a defensible path forward.
Engagements can focus on a single result or span a broader testing program. The starting point is the scientific question and the decision the evidence needs to support.
01
Define the question
Clarify the compound, endpoint, existing evidence, and regulatory context.
02
Evaluate the evidence
Examine study quality, biological relevance, and gaps in the data.
03
Recommend next steps
Develop a proportionate testing or interpretation strategy for the decision ahead.
People behind the work
About us
Recio LLC brings together deep toxicology judgment and practical scientific informatics to help research teams turn complex evidence into clear decisions.
Genetic & investigative toxicology
Leslie Recio, PhD, DABT, ATS
Les is an independent consultant with more than 35 years of investigative toxicology research. A former Chief Scientific Officer at ScitoVation and Integrated Laboratory Systems, he advises on genotoxicity, regulatory interpretation, toxicogenomics, and human-relevant testing methods. He has served on the OECD Genetic Toxicology Expert Working Group since 2014 and contributed to test guidelines 470 and 490.
Scientific informatics & systems
Aaron Phillips
Aaron brings 16 years of experience in clinical systems and software engineering at Thermo Fisher Scientific. His work includes technical leadership, system integrations, and validated platforms supporting Phase III COVID-19 vaccine studies. He focuses on the data and technology side of research programs, including informatics design and AI-enabled workflows.
Contact
Have a toxicology question to work through?
Share the scientific challenge and the decision you need to make. Dr. Recio can discuss a focused review or broader consulting engagement.